| Bioactivity | BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells[1]. |
| Invitro | BAA473 (0-33 µM; 24 hours; THP-1-Cas9 cells) treatment induces cell death in LPS-primed THP-1-Cas9 cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | BAA473 |
| Formula | C36H62O5 |
| Molar Mass | 574.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alimov I, et al. Bile acid analogues are activators of pyrin inflammasome. J Biol Chem. 2019 Mar 8;294(10):3359-3366. |