Aβ42-IN-1 free base

CAS: 2434633-17-5 F: C29H26N4O2 W: 462.54

Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base

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Bioactivity	Aβ42-IN-1 free base (compound 1v) is an orally active, high brain exposure γ-secretase modulator. Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0.091 µM, and significantly reduces brain Aβ42 levels in mice. Aβ42-IN-1 free base is a promising compound for the treatment of Alzheimer’s disease[1].
In Vivo	Aβ42-IN-1 free base treatment shows that the CLint value is 84.7 µL/min/mg protein[1]. Animal Model:
Name	Aβ42-IN-1 free base
CAS	2434633-17-5
Formula	C29H26N4O2
Molar Mass	462.54
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sekioka R, et al. Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators. Bioorg Med Chem. 2020 Jan 1;28(1):115132.