| Bioactivity | Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs[2]. | |||||||||
| Invitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. | |||||||||
| Name | Azido-PEG6-NHS ester | |||||||||
| CAS | 2055014-64-5 | |||||||||
| Formula | C19H32N4O10 | |||||||||
| Molar Mass | 476.48 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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Azido-PEG6-NHS ester
CAS: 2055014-64-5 F: C19H32N4O10 W: 476.48
Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azid
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