| Bioactivity | Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction (IC50=1.2 μM) by binding RNA-binding protein Hu antigen R (HuR). The HuR-RNA interactions stabilize many oncogenic mRNAs in tumors. Thus Azaphilone-9 potentially inhibit cancer cell growth and progression[1]. |
| Invitro | Azaphilone-9 是一种 HuR-RNA 抑制剂。HuR 结合并稳定癌基因 Musashi1 (Msi1) 的 AREs 和抗凋亡蛋白 Bcl2 和 XIAP，从而上调其表达，激活 Wnt/Notch 信号通路，抑制细胞凋亡[1]。 |
| Name | Azaphilone-9 |
| CAS | 1448460-87-4 |
| Formula | C21H23BrO5 |
| Molar Mass | 435.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Azaphilone-9
CAS: 1448460-87-4 F: C21H23BrO5 W: 435.31
Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction (IC50=1.2 μM) by binding RNA-binding protein Hu antigen
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