| Bioactivity | Azamulin is an irreversible, highly selective inhibitior of human CYP3Aa. Azamulin has CYP3A inhibition activity with IC50 values range from 0.03-0.24 μM. Azamulin can be used for the research of metabolism and antiinfection[1]. |
| Invitro | Azamulin 具有 CYP3A 抑制活性，IC50 值范围为 0.03-0.24 μM[1]。Azamulin 对 CYP3A 的抑制呈 S 型曲线，并且对底物 7-benzyloxy-4-trifluoromethylcoumarin, testosterone 和 midazolam 表现良好[1]。Azamulin (4.8 μM; 10 min) 在 NADPH 存在的情况下抑制约 95% 的睾酮 6β-羟化酶活性[1]。Azamulin 在乙腈中储存长达 12 天时表现出良好的化学稳定性[1]。 |
| Name | Azamulin |
| CAS | 76530-44-4 |
| Formula | C24H38N4O4S |
| Molar Mass | 478.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. David M Stresser, et al. Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible. Drug Metab Dispos. 2004 Jan;32(1):105-12. |