PeptideDB

Avobenzone

CAS: 70356-09-1 F: C20H22O3 W: 310.39

Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection i
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Bioactivity Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist[1][2].
Invitro Avobenzone (EC50=14.1 μM) significantly promots adipogenesis in hBM-MSCs as its positive control obesogenic chemicals. Avobenzone (10 μM) significantly up-regulates mRNA levels of PPARγ during adipogenesis in hBM-MSCs[2].Avobenzone (1-50 μM; 48 hours) inhibits proliferative activities of human trophoblast cells[3].Avobenzone (1-50 μM; 48 hours) induces apoptosis in HTR8/SVneo cells[3].Avobenzone only shows weak ERa agonism and weak AR antagonism[4]. Apoptosis Analysis[3] Cell Line:
Name Avobenzone
CAS 70356-09-1
Formula C20H22O3
Molar Mass 310.39
Transport Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)