Bioactivity | Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. Avobenzone is an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist[1][2]. |
Invitro | Avobenzone (EC50=14.1 μM) significantly promots adipogenesis in hBM-MSCs as its positive control obesogenic chemicals. Avobenzone (10 μM) significantly up-regulates mRNA levels of PPARγ during adipogenesis in hBM-MSCs[2].Avobenzone (1-50 μM; 48 hours) inhibits proliferative activities of human trophoblast cells[3].Avobenzone (1-50 μM; 48 hours) induces apoptosis in HTR8/SVneo cells[3].Avobenzone only shows weak ERa agonism and weak AR antagonism[4]. Apoptosis Analysis[3] Cell Line: |
Name | Avobenzone |
CAS | 70356-09-1 |
Formula | C20H22O3 |
Molar Mass | 310.39 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | 4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |