| Bioactivity | Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity[1][2]. |
| Invitro | Avarone (24, 48, 72 h) 抑制 U937 细胞生长，在 24、48、72 小时的 IC50 值分别为 95.8、52.9、33.5 µM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Avarone 相关抗体: Cell Cytotoxicity Assay[2] Cell Line: |
| In Vivo | Avarone (10 mg/kg; i.p.; once daily for 5 days) 可延长白血病小鼠的寿命[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 55303-99-6 |
| Formula | C21H28O2 |
| Molar Mass | 312.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sakurai J, et al. Highly efficient total synthesis of the marine natural products (+)-avarone, (+)-avarol, (-)-neoavarone, (-)-neoavarol and (+)-aureol. Chemistry. 2008;14(3):829-37. [2]. Müller WE, et al. Potent antileukemic activity of the novel cytostatic agent avarone and its analogues in vitro and in vivo. Cancer Res. 1985 Oct;45(10):4822-6. |