| Bioactivity | Autophagy inducer 7 (Compound SSA) is an Autophagy and Apoptosis inducer. Autophagy inducer 7 activates autophagy by inhibiting Akt/mTOR signaling and the expression of downstream proteins. Autophagy inducer 7 suppresses DNA synthesis and causes a G0-G1 cell-cycle arrest. Autophagy inducer 7 inhibits tumor cell growth[1]. |
| Invitro | Autophagy inducer 7 (72 h) 抑制人肺腺癌细胞系的生长，IC50s 为 1.95 μM (HOP-62)、4.72 μM (A549)、3.05 μM (H1299)[1]。Autophagy inducer 7 (0-10 μM, 24 h) 诱导 HOP-62、A549、H1299 细胞凋亡，但不如 Sulindac sulfide (HY-B1786) 和 Staurosporine (HY-15141) 显著[1]。Autophagy inducer 7 (0-7.5 μM, 24 h) 抑制 HOP-62、A549、 H1299 细胞 DNA 合成，并增加细胞周期 G0-G1 期细胞的百分比[1]。Autophagy inducer 7 (0-7.5 μM, 24 h) 通过抑制 A549 细胞中的 Akt/mTOR/p70S6k 信号传导来诱导自噬并增加自噬通量[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Autophagy inducer 7 相关抗体: Apoptosis Analysis[1] Cell Line: |
| CAS | 944159-20-0 |
| Formula | C24H27FN2OS |
| Molar Mass | 410.55 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. 1.Gurpinar E, et al. A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy. Mol Cancer Ther. 2013 May;12(5):663-74. |
Autophagy inducer 7
CAS: 944159-20-0 F: C24H27FN2OS W: 410.55
Autophagy inducer 7 (Compound SSA) is an Autophagy and Apoptosis inducer. Autophagy inducer 7 activates autophagy by inh
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