| Bioactivity | Autophagonizer is a small molecule autophagy inducer that results in an accumulation of autophagy-associated LC3-II and enhances levels of autophagosomes and acidic vacuoles. Autophagonizer inhibits cell viability and induces cell death in not only cancer cells but also Bax/Bak double-knockout cells with EC50 values of 3-4 μM[1]. |
| CAS | 853136-76-2 |
| Formula | C28H31N5O3S2 |
| Molar Mass | 549.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nguyen J, et al. Facile synthesis of autophagonizer and evaluation of its activity to induce autophagic cell death in apoptosis-defective cell line. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4753-4756. |
Autophagonizer
CAS: 853136-76-2 F: C28H31N5O3S2 W: 549.71
Autophagonizer is a small molecule autophagy inducer that results in an accumulation of autophagy-associated LC3-II and
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