| Bioactivity | Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein (Ligands for Target Protein for PROTAC) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259 (HY-168439). HLB-0532259 shows anti-tumor activity against neuroblastoma[1]. |
| CAS | 2541626-73-5 |
| Formula | C21H23N5O3 |
| Molar Mass | 393.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tang J, et al. Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders. Cell Chem Biol. 2025 Jan 6:S2451-9456(24)00516-6. |
Aurora-A ligand 1
CAS: 2541626-73-5 F: C21H23N5O3 W: 393.44
Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (Kd) value of 0.85 nM.
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