| Bioactivity | Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1]. | ||||||||||||
| Name | Aumitin | ||||||||||||
| CAS | 946293-78-3 | ||||||||||||
| Formula | C24H20ClN5O | ||||||||||||
| Molar Mass | 429.90 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Robke L, et al. Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I. Chem Sci. 2018 Feb 26;9(11):3014-3022. |
Aumitin
CAS: 946293-78-3 F: C24H20ClN5O W: 429.90
Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I
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