Atrial natriuretic factor (1-28) (human, porcine)_product_DataBase

Bioactivity	Atrial natriuretic factor (1-28) (human, porcine) is a potent suppressor of pro-opiomelanocortin (POMC) mRNA but a weak inhibitor of βEP-LI release[1][2].
Invitro	ANF-(1-28) markedly increaseS guanosine 3',5'-cyclic monophosphate (cGMP) from 1.3 +/- 0.3 to 106 +/- 22 pmol cGMP/10(6) cells [50% effective dosage (ED50) = 1.2 nM][1]. 0 --> Atrial natriuretic factor (1-28) (human, porcine) 相关抗体:
In Vivo	ANF-(1-28) (0.5 µg/kg/min) infusion attenuates the rise in plasma creatinine levels by approximately 50% on each day of the study[3].
Name	Atrial natriuretic factor (1-28) (human, porcine)
CAS	91917-63-4
Sequence	Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr
Shortening	SLRRSSCFGGRMDRIGAQSGLGCNSFRY
Formula	C127H205N45O39S3
Molar Mass	3080.46
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. B M Fontoura, et al. Atrial natriuretic factor receptors in cultured renomedullary interstitial cells. Am J Physiol. 1990 Apr;258(4 Pt 1):C692-9. [2]. T T Tan, et al. ANF(1-28) is a potent suppressor of pro-opiomelanocortin (POMC) mRNA but a weak inhibitor of beta EP-LI release from AtT-20 cells. J Endocrinol. 1994 Nov;143(2):R1-4. [3]. D M Pollock, et al. Beneficial effect of the ANF analog A68828 on recovery from ischemic acute renal failure. Ren Fail. 1992;14(2):141-6.

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