| Bioactivity | OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pKd of 8.94 for the motilin receptor. OHM 11638 affects esophageal, lower esophageal sphincter (LES), and gastric motility. OHM 11638 increases LES and gastric pressures, OHM 11638 can be used as prokinetic agents[1][2]. |
| Target | pKd: 8.94 (Motilin Receptor) |
| Name | Atilmotin |
| CAS | 533927-56-9 |
| Sequence | {Phe(Me3)}-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Leu-Lys |
| Shortening | {Phe(Me3)}-VPIFTYGELQRLK |
| Formula | C86H135N20O19+ |
| Molar Mass | 1753.11 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Peeters T L. Motilin and the Discovery and Development of Motilinomimetics. Old Herborn University Seminar Monograph. INSTITUTE FOR MICROBIOLOGY AND BIOCHEMISTRY, 1997, 9: 77-87. [2]. Korimilli A, Parkman HP. Effect of atilmotin, a motilin receptor agonist, on esophageal, lower esophageal sphincter, and gastric pressures. Dig Dis Sci. 2010 Feb;55(2):300-6. |
Atilmotin
CAS: 533927-56-9 F: C86H135N20O19+ W: 1753.11
OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pKd o
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