| Bioactivity | Ataprost (ONO 41483) is an orally active Carboprostacyclin (HY-112322) analogue. Ataprost exhibits 2.6 times more active than Carboprostacyclin in inhibiting ADP-induced platelet aggregation in vitro. Ataprost has the ability to relieve coronary spasm[1]. |
| Target | Platelet aggregation |
| Invitro | Ataprost 抑制人类和狒狒富血小板血浆 (PRP) 中的血小板聚集，ED50 分别为 1.91 ng/mL 和 4.38 ng/mL[1]。 |
| In Vivo | Ataprost (50-200 μg/kg; p.o.; 单剂量) 通过口服的方式，抑制狒狒血小板聚集的 ED50 为 87 μg/kg[1]。Ataprost (i.v.; 单剂量) 通过静脉注射的方式，抑制狒狒血小板聚集的 ED50 为 3.2 μg/kg[1]。 |
| Name | Ataprost |
| CAS | 83997-19-7 |
| Formula | C21H32O4 |
| Molar Mass | 348.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Adaikan PG, et al. Inhibition of platelet aggregation and reversal of vasopressin-induced ECG changes by a carboprostacyclin analogue, ONO 41483, in primates. Prostaglandins Leukot Med. 1982 Sep;9(3):307-20. |