| Bioactivity | Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines[1][2]. | |||||||||
| Invitro | Asukamycin (1-50 μM; 24 h) 以浓度依赖的方式降低五种不同人类细胞系的活力，其 IC50 值为 1-5 μM[1]。Asukamycin (50 μM; 24 and 72 h; THP-1 细胞) 导致细胞内 caspase 8 和 caspase 3 活性显著增加[1]。Asukamycin (0-100 mcg/mL; 细菌, 18 h; 真菌, 72 h) 具有抗菌活性。Asukamycin 在 0.78-12.5 mcg/mL 的浓度范围内抑制革兰氏阳性菌的生长，在 25 mcg/mL 的浓度范围内抑制 Trichophyton mentagrophytes 的生长。 Cell Viability Assay[1] Cell Line: | |||||||||
| Name | Asukamycin | |||||||||
| CAS | 61116-33-4 | |||||||||
| Formula | C31H34N2O7 | |||||||||
| Molar Mass | 546.61 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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Asukamycin
CAS: 61116-33-4 F: C31H34N2O7 W: 546.61
Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an
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