| Bioactivity | Asterric acid is an antibiotic fungal metabolite that completely inhibits the binding of the potent vasoconstrictor endothelin (ET)-1 to the ETA receptor in A10 cells at 0.1 μM.1 Asterric acid derivatives have also been shown to inhibit VEGF-induced tube formation of human umbilical vein endothelial cells at 3-10 μM, which suggests its usefulness as an antiangiogenic agent. |
| CAS | 577-64-0 |
| Formula | C17H16O8 |
| Molar Mass | 348.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ohashi, et al. Asterric acid, a new endothelin binding inhibitor. J. Antibiot. (Tokyo) 45, 1684-1685 (1992). |