| Bioactivity | Aspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii. Aspidin BB has anticancer activity. Aspidin BB induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells[1][2]. |
| Invitro | Aspidin BB (0-100 μM, 24-72 h) 以剂量和时间依赖性方式显着抑制 HO-8910 细胞增殖。处理 72、48 和 24 小时后IC50值分别为 15.02、25.79 和 68.81 μM[1]。Aspidin BB 抑制 Bcl-2 表达并增强 Bax 表达以破坏线粒体外膜，然后引起细胞色素 c 释放导致效应 caspase-3 激活，并进一步切割细胞核中的聚 ADP-核糖聚合酶 (PARP)，最终诱导细胞凋亡[1]。Aspidin BB 通过上调 pRb、E2F1、CDK2、细胞周期蛋白 E 和细胞周期蛋白 A 蛋白在 HO-8910 细胞中引起 S 期阻滞[1]。 |
| Name | Aspidin BB |
| CAS | 584-28-1 |
| Formula | C25H32O8 |
| Molar Mass | 460.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |