| Bioactivity | As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1]. |
| Target | IC50: 9.1 μM (Ebola virus), 18.1 μM (Marburg virus) |
| Invitro | As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV[1]. Cell Proliferation Assay Cell Line: |
| In Vivo | As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration[1]. Animal Model: |
| Name | As-358 hydrochloride |
| CAS | 2374723-26-7 |
| Formula | C18H32ClNO2 |
| Molar Mass | 329.91 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sokolova AS, Yarovaya OI, Zybkina AV, et al. Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process. Eur J Med Chem. 2020;207:112726. |
As-358 hydrochloride
CAS: 2374723-26-7 F: C18H32ClNO2 W: 329.91
As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM,
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