| Bioactivity | Arterolane is an antimalarial agent, with IC50 of both 1.1 nM against P. falciparum Ro73 and W2, respectively. |
| Target | IC50: 1.1 nM (P. falciparum Ro73), 1.1 nM (P. falciparum W2) |
| Invitro | Arterolane (Trioxolane 7; OZ277; RBx-11160) is an antimalarial agent, with IC50s of both 1.1 nM (0.43 ng/mL) against P. falciparum Ro73 and W2, respectively. Arterolane also shows inhibitory activity against several other P. falciparums, with IC50s of 1.0, 1.6, 0.90, 0.91, 1.4, 1.5, 0.83, and 0.84 ng/mL for P. falciparum K1, Fc27, FVO, NF54, HB3, FCB1, ITG2-F6, and MAD20, respectively[1]. |
| Name | Arterolane |
| CAS | 664338-39-0 |
| Formula | C22H36N2O4 |
| Molar Mass | 392.53 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
| Reference | [1]. Vennerstrom JL, et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature. 2004 Aug 19;430(7002):900-4. |