| Bioactivity | Artemisinin-13C,d4 is 13C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。Artemisinin (Qinghaosu) (25 or 50 μM; 24 hours) 浓度依赖性地抑制 Aβ25-35 诱导的 PC12 细胞毒性[2]。 Artemisinin (1-100 μM; 24 hours) 以剂量依赖性方式选择性地抑制癌细胞生长，其对 UMRC-2 细胞和 CAKI-2 细胞的 IC50 值分别为23.97, 31.30 μM[3]。 Artemisinin (25, 50 μM; 24 hours) 以剂量依赖性方式抑制 UMRC-2 和 CAKI-2 细胞中 AKT 的磷酸化[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Artemisinin-13C,d4 相关抗体: |
| In Vivo | Artemisinin (gavage; 20 mg/kg/day; for two weeks) 抑制 UMRC-2 异种移植肿瘤的生长[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C1413CH18D4O5 |
| Molar Mass | 287.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108. [3]. Zeng Z, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633. |
Artemisinin-13C,d4
CAS: F: C1413CH18D4O5 W: 287.35
Artemisinin-13C,d4 is 13C and deuterated labeled Artemisinin (HY-B0094). Artemisinin (Qinghaosu), a sesquiterpene lacton
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