| Bioactivity | Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1]. |
| Name | Aristolactam BIII |
| CAS | 53948-10-0 |
| Formula | C18H15NO4 |
| Molar Mass | 309.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Miri Choi, et al. Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes. Phytomedicine. 2021 Nov:92:153695. |
Aristolactam BIII
CAS: 53948-10-0 F: C18H15NO4 W: 309.32
Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Arist
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