| Bioactivity | Arcopilin A (compound Arcopilin A(1))is an antibacterial agent. Arcopilin A has weak inhibitory effects on fungal pathogens and Gram-positive bacteria, with IC50 values of 8.9 μg/mL and 14 μg/mL for cells KB-3-1 and L929, but it can effectively destroy preformed biofilms of Staphylococcus aureus. Arcopilin A can enhance the activities of gentamicin (GM; HY-K1050) and vancomycin (Vac; HY-B0671) by 115 and 31 times, respectively[1]. |
| Invitro | Arcopilin A 在 15.6- 250 μg/mL 的浓度范围内，对预成型生物膜的破坏效果约为 50-60%，在低至 3.9 和 7.8 μg/mL 的浓度下也能抑制金黄色葡萄球菌的生长[1]。Arcopilin A 对 B.subtilis DSM 10，S.aureus DSM 346，S.pombe DSM 70572，C.albicans DSM 1665，M.hiemalis DSM 2656 的 MIC 值均为 66.7 μg/mL，对 S.aureus DSM 1104 的 MIC 值为 31.3 μg/mL[1]。Arcopilin A (3.9-31.1 μg/mL) 降低生物膜代谢活性，呈剂量依赖性[1]。Arcopilin A (2-7.8 μg/mL) 抑制金黄色葡萄球菌 DSM 1104 浮游细胞生长[1]。Arcopilin A (3.9-7.8 μg/mL，24 h) 与 GM 以及 Vac 联用时，对金黄色葡萄球菌 DSM 1104 浮游细胞有协同作用，所建抗生素的 MIC 值分别从 15.6 降至 0.13 μg/mL 和从 2 降至 0.065 μg/mL。联合处理显著提高了 GM 和 Vac 的效力，分别达到 115 倍和 31 倍[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Arcopilin A 相关抗体: |
| Formula | C22H27NO4 |
| Molar Mass | 369.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Esteban Charria-Girón, et al. Arcopilins: A New Family of Staphylococcus aureus Biofilm Disruptors from the Soil Fungus Arcopilus navicularis. J Med Chem. 2024 Aug 14. |