| Bioactivity | Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity [1][2]. |
| Invitro | Arborinine (0, 5, 15, 30 µM; 48 h) 增加 H3K4me1/2、H3K9me1/2、E-cad 蛋白的表达[1]。Arborinine (20 µM) 降低 786O 细胞中 UBE2O 蛋白水平的表达[1]。Arborinine (20 µM) 诱导细胞周期停滞在 S 期并抑制细胞凋亡[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | Arborinine (40、80 mg/kg；灌胃； 21 天) 在小鼠体内显示出抗肿瘤活性[2]。 Animal Model: |
| Name | Arborinine |
| CAS | 5489-57-6 |
| Formula | C16H15NO4 |
| Molar Mass | 285.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Feng C, et al. Arborinine from Glycosmis parva leaf extract inhibits clear-cell renal cell carcinoma by inhibiting KDM1A/UBE2O signaling. Food Nutr Res. 2022 Sep 16;66. [2]. Chu Y, et al. Arborinine, a potential LSD1 inhibitor, inhibits epithelial-mesenchymal transition of SGC-7901 cells and adriamycin-resistant gastric cancer SGC-7901/ADR cells. Invest New Drugs. 2021 Jun;39(3):627-635. |