| Bioactivity | Apratoxin A, a cyanobacterial metabolite, mediates antiproliferative activity through the induction of G1 cell cycle arrest and an apoptotic cascade. Apratoxin A associates with Hsp70/Hsc70 to promote the degradation of Hsp90 client proteins. Apratoxin A can specifically bind the Sec61 complex[1][2][3]. |
| Invitro | Apratoxin A (5, 50 nM; 24, 48 小时) 诱导 G1 细胞周期停滞和细胞凋亡。Apratoxin A 在酵母细胞中没有表现出任何生长抑制活性[1]。 Apratoxin A (50 nM; 1-24 小时) 抑制 STAT3 的 Tyr705 磷酸化[1]。 Cell Cycle Analysis[1] Cell Line: |
| Name | Apratoxin A |
| CAS | 350791-64-9 |
| Formula | C45H69N5O8S |
| Molar Mass | 840.12 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Apratoxin A
CAS: 350791-64-9 F: C45H69N5O8S W: 840.12
Apratoxin A, a cyanobacterial metabolite, mediates antiproliferative activity through the induction of G1 cell cycle arr
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