Apoptosis inducer 30_product_DataBase

Bioactivity	Apoptosis inducer 30 (Compound 15a) is an anticancer agent. Apoptosis inducer 30 induces MCF-7 cells apoptosis through mitochondrial pathway. Apoptosis inducer 30 induces intracellular reactive oxygen species levels and decreases mitochondrial membrane potential, and blocks the cell cycle in the G0/G1 phase. Apoptosis inducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and inhibits tumor growth in a mouse model of breast cancer[1].
Invitro	Apoptosis inducer 30 抑制肿瘤细胞生长，对 A549、HepG2、MCF-7、HeLa、MCF-10A 细胞的 IC50 分别为 1.01、0.91、0.32、0.95、8.09 μM[1]。Apoptosis inducer 30 (100-500 nM, 48 小时) 增加 MCF-7 细胞质中的 Cyt-C 水平，并激活 caspase-9 和 caspase-7[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Apoptosis inducer 30 相关抗体:
Formula	C52H69BrNO4P
Molar Mass	882.99
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang L, et al. Design and synthesis of novel mitochondria-targeted ergosterol peroxide derivatives as potential anti-cancer agents. Bioorg Chem. 2024 Oct 1;153:107862.

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