| Bioactivity | Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and apoptosis through activating JNK signaling pathway in lung cancer cells[1]. |
| Invitro | Apoptosis inducer 17（化合物 CP；0.027-60 μM；72 h）抑制细胞增殖，对 H446、H1299 和 SBC-2 细胞的 IC50 值分别为 0.021 μM、0.027 μM 和 0.73 μM[ 1]。Apoptosis inducer 17（化合物 CP；0.03-0.3 μM；24 小时）对集落形成具有优异的抑制作用。JNK-IN-17 在 H446 和 H1299 细胞中诱导剂量依赖性 G2/M 期阻滞[1]。Apoptosis inducer 17（化合物 CP；0.03-0.3 μM；24 小时）通过 caspase 活性介导诱导 H446 和 H1299 细胞凋亡，并且还激活 JNK 信号级联[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Apoptosis inducer 17 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| In Vivo | Apoptosis inducer 17（化合物 CP；10 mg/kg；腹腔注射；每天两次；持续 15 天）显示 H446 细胞生长显着减少，而体重没有任何显着变化[1] 。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C25H27NO7 |
| Molar Mass | 453.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Curcumin-Piperlongumine Hybrid Molecule Increases Cell Cycle Arrest and Apoptosis in Lung Cancer through JNK/c-Jun Signaling Pathway |