Apoptosis inducer 10_product_DataBase

Bioactivity	Apoptosis inducer 10 is a potent apoptosis inducer. Apoptosis inducer 10 shows antiproliferative effect. Apoptosis inducer 10 induces apoptosis in HeLa cancer cells via a mitochondria-dependent endogenous pathway[1].
Invitro	Apoptosis inducer 10 (compound 11) shows cytotoxic activity with IC50s of 7.39, 63.20, 15.28, 15.38, 12.07 µM for HeLa, HL-7702, A549, PC-3, MCF-7 cells, respectively[1].Apoptosis inducer 10 (2.5, 5, 10 µM) inhibits tumor cell colony formation in A549, HeLa, PC-3 and MCF-7 cells[1].Apoptosis inducer 10 (2.5, 5, 10 µM; 48 h) induces apoptosis in HeLa cells in a dose dependent manner[1].Apoptosis inducer 10 (0, 2.5, 5, 10, 20 µM; 72 h) decreases the ratio to the expression of Bcl-2 and Bax in HeLa cells and resultes in the release of cytochrome c, thereby activates caspase-9 and caspase-3, and cleaved PARP proteins[1].
Name	Apoptosis inducer 10
CAS	2379310-39-9
Formula	C27H46N2O2
Molar Mass	430.67
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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