| Bioactivity | Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity. Apoptin-derived peptide promotes apoptosis and necrosis of gastric cancer (GC) cells by regulating PI3K/AKT/ARNT signaling. Apoptin-derived peptide inhibited the invasion and migration of cancer cells, and inhibited the expression and phosphorylation of the subunit p85 of PI3K, which further inhibited the PI3K/AKT pathway involved in the development of gastric cancer[1]. |
| Invitro | Apoptin-derived peptide (40-100 μg/mL, 24 h) 通过抑制 PI3K/AKT 信号通路促进 ARNT 下调，从而逆转 SGC-7901/CDDP 细胞对 CDDP 的耐药性[1]。Apoptin-derived peptide (10-30 μg/mL, 24 h) 抑制 SGC-7901、SGC-7901/CDDP 和 MGC-803 细胞的迁移和侵袭[1]。Apoptin-derived peptide (30-60 μg/mL, 24 h) 增加 SGC-7901/CDDP 细胞对 CDDP 的敏感性[1]。Apoptin-derived peptide (10-20 μg/mL, 24 h) 增加 SGC-7901/CDDP 细胞的 G2/M 期细胞比例并诱导细胞凋亡[1]。Apoptin-derived peptide (10-70 μg/mL, 4-24 h) 对胃癌细胞有很好的抑制作用[1]。 0 --> Apoptin-derived peptide 相关抗体: Cell Viability Assay[1] Cell Line: |
| Name | Apoptin-derived peptide |
| CAS | 2232156-31-7 |
| Sequence | Met-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Pro-Pro-Ser-Lys-Lys-Arg-Ile-Arg-Ile-Gly-Ile-Ala-Gly-Ile-Thr-Ile-Thr-Leu-Ser-Leu-Arg-Pro-Arg-Thr-Ala-Lys-Arg-Arg-Ile-Arg-Leu |
| Shortening | MGRKKRRQRRRKPPSKKRIRIGIAGITITLSLRPRTAKRRIRL |
| Formula | C223H417N89O50S |
| Molar Mass | 5177.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhou D, et al. Apoptin-derived peptide reverses cisplatin resistance in gastric cancer through the PI3K-AKT signaling pathway [J]. Cancer Medicine, 2018, 7(4): 1369-1383. |
Apoptin-derived peptide
CAS: 2232156-31-7 F: C223H417N89O50S W: 5177.33
Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity. Apoptin-derived peptide promotes apoptosis and ne
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