| Bioactivity | Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-XL, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis[1] and autophagy[2]. Apogossypolone also has antifungal activity[3]. |
| Invitro | Apogossypolone (ApoG2) shows improved stability under stressed conditions[1].Apogossypolone (0-1 µM, 72 or 96 h) inhibits WSU-DLCL2 cells growth in a dose-dependent manner[1].Apogossypolone (0-5 µM, 24 or 48 h) interferes with the formation of heterodimers between anti-apoptotic and pro-apoptotic Bcl-2 family members, and leads to cleavage of caspase-3, caspase-9 and PARP[1].Apogossypolone (0-8 µM, 0-72 h) induces apoptotic WSU-DLCL2 cell death in a time- and dose-dependent manner[1].Apogossypolone (0-10 µM, 0-24 h) induces autophagy and promotes ROS generation in HCC cells[2]. Cell Proliferation Assay[1] Cell Line: |
| Name | Apogossypolone |
| CAS | 886578-07-0 |
| Formula | C28H26O8 |
| Molar Mass | 490.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Apogossypolone
CAS: 886578-07-0 F: C28H26O8 W: 490.50
Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2
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