| Bioactivity | Aplyronine A is a specific actin-depolymerizing agent. Aplyronine A has antitumor and apoptosis effect. Aplyronine A can be used for the research of cancer and muscle contraction, cell motility and cell division[1]. |
| Invitro | Aplyronine A (compound 1) has cytotoxicity against HeLa S3 cells with an IC50 value of 0.01 nM[1].Aplyronine A depolymerizes fibrous actin (F-actin) and inhibits the polymerization of actin with an EC50 value of 1.3 μM in vitro actin-depolymerizing assay[1].Aplyronine A (0-1 μM, 0-2 h) causes prominent caspase-dependent apoptosis in human epithelial carcinoma HeLa S3 cells[1]. Aplyronine A (100 nM, 24 h) causes malfunction of cell adhesion and dephosphorylation of focal adhesion kinase with apoptosis[1]. Western Blot Analysis[1] Cell Line: |
| Name | Aplyronine A |
| CAS | 151923-84-1 |
| Formula | C59H101N3O14 |
| Molar Mass | 1076.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Aplyronine A
CAS: 151923-84-1 F: C59H101N3O14 W: 1076.44
Aplyronine A is a specific actin-depolymerizing agent. Aplyronine A has antitumor and apoptosis effect. Aplyronine A can
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