Antiviral agent 58_product_DataBase

Bioactivity	broad-spectrum antiviral activity against enveloped viruses, including IAV, respiratory syncytial virus (RSV). anti-IAV effects in vitro and in vivo.；https://www.nature.com/articles/s41401-024-01331-7（J1）；新品上线，张雨新分子推荐20240711
Invitro	Antiviral agent 58 (Compound J1) (6.25-200 μM; 48 h) 在 A549、MDCK、Vero-E6、HRT18 细胞中在 200μM 浓度下对细胞具有较低的细胞毒作用[1]。Antiviral agent 58 能抑制 H1N1、H7N9、H5N1 和 H3N2 等 IAV 毒株以及奥司他韦耐药 (HY-13317) 毒株的感染, IC50 值在 7.81-15.65 μM 之间[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Antiviral agent 58 相关抗体:
In Vivo	Antiviral agent 58 (Compound J1) (15-60 mg/kg; 口服; 一天一次，连续 5 天) 在 BALB/c 小鼠中显著减轻 IAV 诱导的肺损伤[1]。model: IAV lung injury BALB/c mouse model[1].dose: 15 mg/kg; 30 mg/kg; 60 mg/kgadministration: Oral, once daily for 5 daysresult:Increased the survival rate of virus-infected mice, and decreased viral titer, lung index and lung inflammation damage. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	939655-35-3
Formula	C24H18ClN3O
Molar Mass	399.87
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li Y, et al. A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity[J]. Acta Pharmacologica Sinica, 2024: 1-14.

PeptideDB

Antiviral agent 58

CAS: 939655-35-3 F: C24H18ClN3O W: 399.87