| Bioactivity | Antiviral agent 54 (compound 33) is a broad-spectrum and orally active antiviral agent. Antiviral agent 54 shows antiviral activity for ZIKV, HCoV-OC43 and influenza A virus (IVA). Antiviral agent 54 decreases the ZIKV RNA and protein level[1]. |
| Target | EC50: 0.39 µM (ZIKV); 2.28 µM (HCoV-OC43); 2.69 µM (influenza A) |
| Invitro | Antiviral agent 54 (compound 33) (5, 2.5, 1.25, 0.625 µM; 48 h) 以剂量依赖性方式降低 ZIKV NS5 蛋白和 RNA 水平[1]。Antiviral agent 54 对 ZIKV、HCoV-OC43 和甲型流感病毒 (IVA) 具有抗病毒活性，EC50 值分别为 0.39、2.28、2.69 µM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Antiviral agent 54 相关抗体: Western Blot Analysis[1] Cell Line: |
| Formula | C23H37N7 |
| Molar Mass | 411.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ji Y, et al. Design, synthesis, and antiviral activity of 1-aryl-4-arylmethylpiperazine derivatives as Zika virus inhibitors with broad antiviral spectrum. Bioorg Med Chem. 2024 Apr 1;103:117682. |