| Bioactivity | Antiviral agent 24 is a potent antiviral agent with EC50 values of 0.101, 19.9, 91.2 µM for EV71, CVA21, EV68, respectively. Antiviral agent 24 inhibits METTL3/METTL14 activity in a dose-dependent manner[1]. | |||||||||
| Invitro | Antiviral agent 24 (compound 25) (0-1000 µM) 抑制 METTL3/METTL14 复合物活性,EC50 值为 129 µM[1]。 | |||||||||
| Name | Antiviral agent 24 | |||||||||
| CAS | 23661-03-2 | |||||||||
| Formula | C18H18F3N5O4 | |||||||||
| Molar Mass | 425.36 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
|
|||||||||
| Reference | [1]. Salerno M, et al. Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71. Eur J Med Chem. 2022 Nov 24;246:114942. |