Antiviral agent 15_product_DataBase

Bioactivity	Antiviral agent 15 (Compound 15f) is a Clofazimine derivative with antiviral effects. Antiviral agent 15 inhibits both rabies virus and pseudo-typed SARS-CoV-2 with EC50 values of 1.45 μM and 14.6 μM, respectively[1].
Invitro	Antiviral agent 15 (Compound 15f) affects the rabies and SARS-CoV-2 proliferation by targeting G or S protein to block the viral membrane fusion, as well as binding to L protein or nsp13 to inhibit viral biosynthesis, respectively, and thus synergistically exerted antiviral effect[1].
In Vivo	In Kunming mice, Antiviral agent 15 (Compound 15f) is given orally in a single-dosing experiment at 0 mg/kg, 200 mg/kg, 400 mg/kg, 600 mg/kg and 800 mg/kg, respectively. The mice are closely monitored for 7 days, and all the surviving mice had glossy hair, fleshy body and good appetite[1].
Name	Antiviral agent 15
Formula	C27H24FN5O
Molar Mass	453.51
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Xintong Zhang, et al. Clofazimine derivatives as potent broad-spectrum antiviral agents with dual-target mechanism. Eur J Med Chem. 2022 Apr 15;234:114209.

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