Antitumor photosensitizer-5

CAS: F: C53H43F12N11O2P2RuS W: 1289.04

Antitumor photosensitizer-5 (Ru2) is a photosensitizer which effectively target tumor mitochondria with an IC50 of 0.3

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Bioactivity	Antitumor photosensitizer-5 (Ru2) is a photosensitizer which effectively target tumor mitochondria with an IC50 of 0.3 μM for phototoxicity to A549 cells. Under 460 nm light irradiation, antitumor photosensitizer-5 induces the generation of reactive oxygen species and NADH depletion, causes mitochondrial damage and activation of caspase-3, inducing apoptosis and suppressing cell migration. Antitumor photosensitizer-5 has the potential to prevent the growth of malignant tumors, therefore, shows the potential to be applied to photodynamic therapy[1].
Target	Nicotinamide adenine dinucleotide (NADH)
Invitro	Antitumor photosensitizer-5 (10 μM, 4 h) 可使生物素受体阳性的 A549 细胞荧光信号显著增加 (32.08 倍)，而生物素受体阴性的 BHK 细胞荧光信号增加可忽略 (7.35 倍) [1]。Antitumor photosensitizer-5 (0.391-100 μM, 24 h) 在 BHK 细胞和 A549 细胞中均表现出光毒性，在 100 μM 无光条件下表现出最小的细胞毒性，细胞存活率超过 75%[1]。Antitumor photosensitizer-5 (10 μM, 4 h) 与线粒体探针 Mito-Tracker Green 的 Pearson 共定位系数为 0.87[1]。Antitumor photosensitizer-5 (0.15-0.6 μM, 24 h) 在 460 nm 光照射 15 min 后，线粒体膜电位探针荧光强度比呈浓度依赖性降低，表明线粒体损伤，而 ROS 探针荧光强度呈浓度依赖性增加，表明 ROS 的高效生成[1]。Antitumor photosensitizer-5 (0.15-0.6 μM, 24 h) 在光照后可引起 A549 细胞发生凋亡，在黑暗条件下细胞凋亡水平基本不变，光照条件下使活化 caspase-3 与 DNA 迁移损伤增加，使细胞 NADH 含量降低[1]。Antitumor photosensitizer-5 (0.15-0.6 μM, 24 h/48 h) 在 460 nm 光照后抑制 A549 细胞的迁移[1]。 0 --> Antitumor photosensitizer-5 相关抗体: Cell Viability Assay[1] Cell Line:
In Vivo	Antitumor photosensitizer-5 (10 mg/kg, i.tu. 一次，24 d) 在 460 nm 光照射后显著抑制肿瘤生长，且对正常器官无严重不良影响[1]。 Animal Model:
Name	Antitumor photosensitizer-5
Formula	C53H43F12N11O2P2RuS
Molar Mass	1289.04
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Guoqiang Shao, et al. Biotin-conjugated Ru(II) complexes with AIE characteristics as mitochondria-targeted photosensitizers for enhancing photodynamic therapy by disrupting cellular redox balance. European Journal of Medicinal Chemistry. 2023，Volume 264，115985.