Antitumor agent-91_product_DataBase

Bioactivity	Antitumor agent-91 is a cyclic phosphate ester derivative with anticancer and anti-proliferative activities. Antitumor agent-91 has potential application in human castration resistant prostate cancer and pancreatic cancer[1].
Invitro	Antitumor agent-91 (Compound 18c) 对 MM1. S、BxPC-3、MP-2、22Rv1、MV4-11、Jeko-1 和 HUH7 细胞具有抗肿瘤活性，IC50 值分别为 3.6 nM、16.5 nM、12.5 nM、10.6 nM、5.4 nM、19.2 nM 和 16.2 nM[1]。 Western Blot Analysis[1] Cell Line:
In Vivo	Antitumor agent-91 (Compound 18c) (50 mg/kg；腹腔注射；一周两次持续四周) 在植入 22Rv1 肿瘤的去势雄性 Balb/c 裸鼠模型中显著抑制了肿瘤增长[1]。Antitumor agent-91 在比格犬中的药代动力学 (PK) 参数[1]Route
Name	Antitumor agent-91
Formula	C18H18F2N3O8P
Molar Mass	473.32
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhang L, et al. Design, Synthesis, and Anti-Cancer Evaluation of Novel Cyclic Phosphate Prodrug of Gemcitabine. J Med Chem. 2023 Mar 23;66(6):4150-4166.

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