| Bioactivity | Antitumor agent-82 (compound 6g) is a potent anti-tumor agent. Antitumor agent-82 shows anti-proliferative activity. Antitumor agent-82 induces cell Autophagy by the ATG5/ATG7 signaling pathway[1]. |
| Invitro | Antitumor agent-82 (compound 6g) (0-100 µM; 48 h) shows anti-proliferative activity with IC50s of 24.8, 13.5, 11.5, 2.71, 2.02, 4.53 µM for BGC-823, MCF7, A375, 786-O, HT-29, Blu-87 cells, respectively[1].Antitumor agent-82 (0-4 µM; 0-7 days) inhibits cell growth in a dose and time-dependent manner against HCT116 cells[1].Antitumor agent-82 (0-5 µM; 0-60 h) activates autophagy by the ATG5/ATG7 signaling pathway in HCT116 cells[1]. Cell Proliferation Assay[1] Cell Line: |
| In Vivo | Antitumor agent-82 (45 mg/kg; i.p.; every two days for 16 days) shows anti-cancer activity for mouse[1]. Animal Model: |
| Name | Antitumor agent-82 |
| Formula | C32H42N6 |
| Molar Mass | 510.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ao J,et al. Design, synthesis and pharmacological evaluation of β-carboline derivatives as potential antitumor agent via targeting autophagy. Eur J Med Chem. 2022 Nov 26;246:114955. |