Antitumor agent-78_product_DataBase

Bioactivity	Antitumor agent-78 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-78 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-78 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells[1].
Invitro	Antitumor agent-78 (compound 2b) (30 μM; 4 h) exhibits good liposoluble and improved cellular uptake in A549 cancer cells[1].Antitumor agent-78 (20 μM; 36 h) produces cytotoxicity by inducing apoptosis of A549 cancer cells[1].Antitumor agent-78 (20 μM; 24 h) results in significant down-regulation of Bcl-2 and upregulation of Bax, also leads to E-cadherin increase, Vimentin decrease[1].Antitumor agent-78 (20 μM; 24 h) arrests cell cycle at S phase and G2/M phase[1].Antitumor agent-78 (10 μM; 12 h) inhibits cells migration with inhibition rate of 53%[1]. Apoptosis Analysis[1] Cell Line:
Name	Antitumor agent-78
Formula	C13H19F3N2O5Pt
Molar Mass	535.38
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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