| Bioactivity | Antitumor agent-67 (compound 3) is a potent antitumor agent. Antitumor agent-67 has highly selective toxicity to cancer cells and lower damage to normal cells. Antitumor agent-67 can be activated by NQO1 and effectively liberate podophyllotoxin and kill tumor cells. Antitumor agent-67 significantly suppresses cancer growth in HepG2 xenograft models without obvious toxicity[1]. |
| Target | NQO1 |
| Invitro | Antitumor agent-67 (compound 3) has antiproliferative activity against HepG2, A549, LO2, HepG2/Hyp, A549/Hyp and A549/T with IC50s of 84 ± 9 μM, 100 ± 19 μM, 312 ± 34 μM, 113 ± 13 μM, 185 ± 24 μM and 197 ± 29 μM[1]. |
| Name | Antitumor agent-67 |
| Formula | C45H47NO13 |
| Molar Mass | 809.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Qu Y, et al. Synthesis and biological evaluation of NQO1-activated prodrugs of podophyllotoxin as antitumor agents. Bioorg Med Chem. 2020;28(24):115821. |