| Bioactivity | Antitumor agent-177 (compound 57), a non-steroidal NSC12 derivative, shows potent FGF2 binding affinity with a Kd of 24 μM by SPR. Antitumor agent-177 efficiently binds FGF2 and inhibits FGFR activation in multiple myeloma (MM) cells. Antitumor agent-177 significantly inhibits the formation of HSPG/FGF2/FGFR1 ternary complexes. Antitumor agent-177 exerts a potent anti-tumor activity on MM cell lines in vitro and in vivo[1]. |
| Formula | C28H21F7O4 |
| Molar Mass | 554.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sara Taranto, et al. Discovery of novel FGF trap small molecules endowed with anti-myeloma activity. Pharmacol Res. 2024 Jul 3:206:107291. |