| Bioactivity | Antitumor agent-153 (compound 11b) is an optimized H2A histone ubiquitination inhibitor based on PRT4165 (HY-19817). Antitumor agent-153 inhibits the viability of human osteosarcoma U2OS cells and reduces histone H2A monoubiquitination, exhibiting anticancer activity.[12][1]. |
| Invitro | Antitumor agent-153 对 U2O 细胞的抑制效力 IC50 为 5.86 μM，并在 30 μM 条件下完全抑制其增殖[1]。H2AK119ub1 水平的降低会扰乱肿瘤的发展和癌细胞的生长。而 Antitumor agent-153 (24-96 μM; 1 h) 可以剂量依赖性方式显着降低 U2O 细胞中的 H2AK119ub1 水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Antitumor agent-153 相关抗体: Cell Viability Assay[1] Cell Line: |
| Formula | C16H8N2O6 |
| Molar Mass | 324.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ni S, et al. Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule. Bioorg Med Chem Lett. 2024 Jun 1;105:129759. |