| Bioactivity | Antitumor agent-149 (Compound 3) is an analogue of Echinomycin (HY-106101). Antitumor agent-149 inhibits HIF-1α-mediated transcription. Antitumor agent-149 induces cancer cell apoptosis. Antitumor agent-149 inhibits tumor growth in SW620 xenograft mice model[1]. |
| Invitro | Antitumor agent-149 对 SW620 和 MIA PaCa-2 细胞具有细胞毒性，IC50s 分别为 0.85 nM 和 1.4 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Antitumor agent-149 相关抗体: |
| CAS | 2368983-54-2 |
| Formula | C52H64N10O14S |
| Molar Mass | 1085.19 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kojima K, et al. Synthesis and biological evaluation of echinomycin analogues as potential colon cancer agent. Sci Rep. 2024 Apr 1;14(1):7628. |
Antitumor agent-149
CAS: 2368983-54-2 F: C52H64N10O14S W: 1085.19
Antitumor agent-149 (Compound 3) is an analogue of Echinomycin (HY-106101). Antitumor agent-149 inhibits HIF-1α-mediate
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