Antitumor agent-133_product_DataBase

Bioactivity	Antitumor agent-133 (compound 4d) is a bis-isatin derivative, with activities against Huh1 (IC50=17.13 μM) and Huh7 (IC50=8.27 μM). Antitumor agent-133 induces cell autophagy and inhibits tumor growth through regulation of LC3BII, ATG5 and p62 proteins[1].
Invitro	Antitumor agent-133 对癌细胞具有选择性[1]。Antitumor agent-133 (0-100 μM, 48h) 通过调节LC3B（I 和 II），ATG5 以及 p62 的表达，诱导细胞自噬[1]。 0 --> Antitumor agent-133 相关抗体:
In Vivo	Antitumor agent-133（15 mg/kg，腹腔注射，每两天一次共14天）可以抑制肿瘤在 NCG 小鼠 Huh1 异种移植模型内的生长，并且具有低毒性[1]。 Animal Model:
Name	Antitumor agent-133
Formula	C27H24Br2N4O8
Molar Mass	692.31
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li Z, et al., Synthesis, biological activity evaluation and mechanism of action of novel bis-isatin derivatives as potential anti-liver cancer agents. Bioorg Med Chem Lett. 2024 Jan 13;99:129613. doi: 10.1016/j.bmcl.2024.129613

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