Antitumor agent-115_product_DataBase

Bioactivity	Antitumor agent-115 (SS-12) is an effective anti-tumor compound with an IC50 value of 0.34 μM-24.14 μM for cell line 4T1. Antitumor agent-115 can block the cell cycle of mouse breast cancer cell line 4T1, reduce the mitochondrial membrane potential, and induce apoptosis, and the IC50 value is 8-25 μmol/L for cell viability. Antitumor agent-115 can be used for breast cancer research[1].
Invitro	Antitumor agent-115 (SS-12) (1.25 μM, 10 μm, 40 μM, 24 小时) 主要通过使细胞周期停滞在 G0/G1 阶段来诱导 4T1 细胞凋亡[1]。Antitumor agent-115 (15 μM, 30 μM, 60 μM, 24小时) 抑制 4T1 细胞的迁移和侵袭[1]。Antitumor agent-115 (10 μM, 24小时) 通过线粒体途径诱导 4T1 细胞凋亡[1]。 Cell Viability Assay[1] Cell Line:
In Vivo	Antitumor agent-115 (SS-12) (10 mg stachydrine/kg equivale, 200 μL, 口服给药) 在大鼠体内具有较高的生物利用度[1]。 Antitumor agent-115 (0.1 mL/10 g, 口服给药) 在乳腺癌模型小鼠中具有抗肿瘤作用，并改善模型小鼠脾脏的形态结构[1]。 Animal Model:
Name	Antitumor agent-115
CAS	2759277-20-6
Formula	C19H38ClNO2
Molar Mass	347.96
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zeng H, et al. Synthesis, characterization and anti-breast cancer activities of stachydrine derivatives. Eur J Med Chem. 2023 Jul 26;259:115679.

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