| Bioactivity | Antitubulin agents-1 is an antitubulin agent that induces disruption of the microtubules (Microtubule/Tubulin) and increases α-tubulin acetylation. Antitubulin agents-1 has anticancer effects[1]. |
| Invitro | Antitubulin agents-1 (compound 143) shows cytotoxic in human neuroblastoma SH-SY5Y cells with an EC50 of 102 nM[1].Antitubulin agents-1 (compound 143; 1 μM; for 16 h) is able to induce a statistically significant G2/M cell cycle arrest at 1 μM. Antitubulin agents-1 also inhibits polymerization[1].Antitubulin agents-1 (compound 143; 0.1-1 μM; for 16 h) leads to a significant increase in tubulin acetylation[1]. Cell Cycle Analysis[1] Cell Line: |
| Name | Antitubulin agent 1 |
| Formula | C21H19N3O3 |
| Molar Mass | 361.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Arash Foroutan, et al. Identification of novel aza-analogs of TN-16 as disrupters of microtubule dynamics through a multicomponent reaction. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114895. |