Antituberculosis agent-10_product_DataBase

Bioactivity	Antituberculosis agent-10 (Compound 9) has excellent antibacterial activity against Mycobacterium tuberculosis (MIC = 0.3 μM). Antituberculosis agent-10 inhibits protein synthesis by targeting the 50S ribosomal subunit of the bacterium, thus exerting its antibacterial effect. Antituberculosis agent-10 is orally active[1].
Invitro	Antituberculosis agent-10 (72 h) 对 HepG2 细胞的线粒体蛋白合成 (MPS) 的抑制没有活性 (IC50 = 150 μM)，但其代谢产物显示出线粒体毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Antituberculosis agent-10 相关抗体:
In Vivo	Antituberculosis agent-10 (i.g.; 5-50 mg/kg; 每天一次或者每天两次) 在感染 C3HeB/FeJ 小鼠内表现出优异的渗透性和持续的活性[1]。Antituberculosis agent-10 ((i.g.; 4 mg/kg,每天两次持续一周,之后每天一次) 处理显著减少了 Mtb 感染的狨猴的结核病灶的体积，具有强大的抗菌活性[1]。药代动力学分析[1] Route
CAS	2095636-19-2
Formula	C17H17FN2O4S
Molar Mass	364.39
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Boshoff HIM, et al. Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities. ACS Infect Dis. 2024 Apr 6.

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