| Bioactivity | Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA[1]. |
| Target | IC50: 0.71 μM (T. brucei) |
| Name | Antitrypanosomal agent 7 |
| CAS | 2492436-38-9 |
| Formula | C23H31Cl2N5O2 |
| Molar Mass | 480.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Popov AB,et al. DNA/RNA binding and in vitro ADME profiling of novel imidazoline-substituted 2-arylbenzimidazoles. Eur J Med Chem. 2020 Dec 1;207:112802. |
Antitrypanosomal agent 7
CAS: 2492436-38-9 F: C23H31Cl2N5O2 W: 480.43
Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypa
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