| Bioactivity | Antitrypanosomal agent 12 is a C20-phenylthiourea with trypanocidal and cytotoxic activities. Antitrypanosomal agent 12 shows antitrypanosomal activity with 50% growth inhibition (GI50) values of 0.22 μM. Antitrypanosomal agent 12 induces faster cell swelling in bloodstream-form trypanosomes than Salinomycin (HY-15597)[1]. |
| Invitro | Antitrypanosomal agent 12 (化合物 4d) (100 mM；60 分钟) 在 T. brucei 血流形式中表现出比天然 Salinomycin 更快的细胞肿胀活性[1]。Antitrypanosomal agent 12 显示出对 T. brucei 有优于 HL-60 细胞的选择性，MIC 值分别为 1 μM (T. brucei) 和 10 μM (HL-60 细胞)[1]。 |
| Name | Antitrypanosomal agent 12 |
| Formula | C49H77N2NaO10S |
| Molar Mass | 909.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Antoszczak M, et al. Synthesis of urea and thiourea derivatives of C20-epi-aminosalinomycin and their activity against Trypanosoma brucei. Eur J Med Chem. 2023 Mar 15;250:115241. |
Antitrypanosomal agent 12
CAS: F: C49H77N2NaO10S W: 909.20
Antitrypanosomal agent 12 is a C20-phenylthiourea with trypanocidal and cytotoxic activities. Antitrypanosomal agent 12
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