| Bioactivity | Antiproliferative agent-57 (compound M2) is a tumor angiogenesis inhibitor. Antiproliferative agent-57 inhibits the secretion of VEGF in SiHa cells under hypoxic conditions (IC50=0.68 μM) without inducing cytotoxicity. Antiproliferative agent-57 can modulate the PI3K/AKT/mTOR and MAPK signaling pathways in tumor cells to inhibit the expression of HIF-1α and VEGF in tumor tissues[1]. |
| Formula | C34H37ClN4O9 |
| Molar Mass | 681.13 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Deng H, et al. Design, Synthesis, and Evaluation of Antitumor Activity in Pseudolaric acid B Azole Derivatives: Novel and potent Angiogenesis inhibitor via Regulation of the PI3K/AKT and MAPK Mediated HIF-1/VEGF Signaling Pathway[J]. European Journal of Medicinal Chemistry, 2024: 116813. |
Antiproliferative agent-57
CAS: F: C34H37ClN4O9 W: 681.13
Antiproliferative agent-57 (compound M2) is a tumor angiogenesis inhibitor. Antiproliferative agent-57 inhibits the secr
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