Antiproliferative agent-42_product_DataBase

Bioactivity	Antiproliferative agent-42 (compound 7m) is a dihydrodipyrrolo compound. Antiproliferative agent-42 showed antiproliferative activity against Panc-1 cell line with an IC50 value of 12.54 μM[1].
Invitro	Antiproliferative agent-42 (0-100 μM, 48 h) 对 Panc-1、 PC3、 MDA-MB-231 细胞有抑制作用，IC50 分别是 12.5 μM、17.7 μM,、and 13.1 μM[1]。Antiproliferative agent-42 (12.54 μM, 48 h) 在 Panc-1 细胞中能够诱导 sub-G1 期阻滞[1]。Antiproliferative agent-42 (12.54 μM) 在 Panc-1 细胞中使得 cleaved-caspase-3 和 caspase-3 蛋白下调，而 pro-caspase-3 蛋白水平保持不变[1]。 0 --> Antiproliferative agent-42 相关抗体: Apoptosis Analysis[1] Cell Line:
Name	Antiproliferative agent-42
Formula	C18H13N5O4
Molar Mass	363.33
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lish A B,et al. Synthesis and Biological Evaluation of 12-Aryl-11-hydroxy-5,6-dihydropyrrolo[2″,1″:3′,4′]pyrazino[1′,2′:1,5]pyrrolo[2,3‑d]pyridazine-8(9H)‑one Derivatives as Potential Cytotoxic Agents [J].[2023-11-08]. [2]. Barghi Lish, Azam, et al. "Synthesis and Biological Evaluation of 12-Aryl-11-hydroxy-5, 6-dihydropyrrolo [2 ″, 1 ″: 3′, 4′] pyrazino [1′, 2′: 1, 5] pyrrolo [2, 3-d] pyridazine-8 (9 H)-one Derivatives as Potential Cytotoxic Agents." ACS Omega (2023).

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